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Goals of Mitogenome

  Provide all the information relevant to Mitochondrial Genome.

  Provide a learning environment and a reference material.

  Became an information hub for the mitochondrial genome.


The world of mitochondria

The mitochondria is the site of energy production in the cell. The mitochondria consists of a double membrane system. The outer membrane is smooth and the inner membrane has convoluted folds. The mitochondria can divide independently of the cell and contains its own circular, double-stranded DNA; the mitochondrial DNA (mtDNA) [1]. According to the endosymbiont hypothesis, the mitochondria and its genome are the remnants of a free-living eubacterial ancestor, probably an extant a-proteobacterium, which was engulfed by a eukaryotic host cell and later established a symbiotic relationship with it [2].

References:
[1] Robert F. Weaver. Molecular Biology. Ed. WCB McGraw-Hill. (1999).
[2] Y. Sugiyama, Y. Watase, M. Nagase, N. Makita, S. Yagura,  A. Hirai and M. Sugiura. The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants. Mol Gen Genomics (2005) 272: 603–615.